A total synthesis of (±)-cedrol and (±)-cedrene via an intramolecular Diels–Alder reaction

Synthesis of crispine A analogues via an intramolecular Schmidt reaction

An intramolecular Schmidt reaction strategy for the synthesis of various derivatives of crispine A using azido-ketone as a key intermediate is described.

Oxacycle Synthesis via Intramolecular Reaction of Carbanions and Peroxides

The intramolecular reaction of dialkyl peroxides with carbanions, generated via chemoselective metal-heteroatom exchange or deprotonation, provides a new approach to cyclic ethers. Applied in tandem with C-C bond formation, the strategy enables a one-step annelation to form oxaospirocycles.

The asymmetric intramolecular Heck reaction in natural product total synthesis.

Total synthesis of (+/-)-phomactin B2 via an intramolecular cyclohexadienone annulation of a chromium carbene complex.

Phomactins are novel platelet activating factor (PAF) antagonists isolated from the culture of marine fungus Phoma sp.1 Members of the phomactin family share a unique [9.3.1] pentadecane ring system, and their biosynthetic pathway shares a branchpoint with the taxane family of natural products.1,2 Substantial synthetic efforts have been described in the literature toward the synthesis of severa...

An effective synthesis of 5,4'-disubstituted flavones via a cesium enolate assisted intramolecular ipso-substitution reaction.

A variety of 5,4'-disubstituted flavones, which are anticipated to be androgen receptor antagonists to treat diseases mediated by the androgen receptor, were synthesized. It was found that an intramolecular ipso-substitution reaction via cesium enolate using 2-fluoro-6-hydroxyacetophenone and various benzoyl chlorides was effective in the preparation of 5-hydroxy-4'-alkylflavones.